Hydrochloric Acid → HCID 59627748、化合物
反応式
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[CH:8]=[C:9]([I:11])[CH:10]=1)=[O:4].[OH-].[Na+].Cl>CO>[I:11][C:9]1[CH:10]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=[C:7]([C:12]2[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[CH:8]=1参加物
5
実験手順
5-Iodo-4′-methyl-biphenyl-3-carboxylic acid methyl ester (280 mg, 0.8 mmol) was added to a mixture of methanol (4 mL) and 2M aqueous NaOH (2 mL). The mixture was stirred for 48 hours at room temperature, then neutralized by addition of 1M aqueous HCl. Solvent was removed under reduced pressure and the mixture was coevaporated twice with toluene to give crude 5-iodo-4′-methyl-biphenyl-3-carboxylic acid, which was used directly in the next step.
後処理
- customSolvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-20903571eb09456ea21cc1894cba1589
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08093275B2
反応ノート
読み込み中…