関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Methoxy-2-methylindole | HCID 70642 | — |
| 反応物 | 4-Chloro-8-(trifluoromethyl)quinoline | HCID 90262 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Quinoline,4-(5-methoxy-2-methyl-1h-indol-3-yl)-8-methyl- | HCID 66651927 | 93.7% |
反応手順
A mixture of 5-methoxy-2-methylindole (346 mg) and 4-chloro-8-trifluoromethylquinoline (380 mg) in NMP (1 ml) and 4M HCl in dioxane (0.1 ml) was heated at 140° C. for 50 min. Aqueous sodium bicarbonate was added and the mixture was extracted with ethyl acetate. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-acetone as eluent) to give the sub-title compound (465 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08093278B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-1212322d85cc4dc092eb8ba137401bee |
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| 出典メモ | uspto-grants-2012_01 |
|---|
