Diphenyl Ether → HCID 178516461、化合物

HRID 418451

反応式

HRID 418451 の反応式
[F:1][CH:2]([F:11])[O:3][C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6].[C:12]1([O:18]C2C=CC=CC=2)C=CC=[CH:14][CH:13]=1.CCCC(C)C>C(#N)C>[F:1][CH:2]([F:11])[O:3][C:4]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:5]=1[N:6]=[CH:14][CH:13]=[C:12]2[OH:18]

参加物

5

反応物 3

HCID 7583Diphenyl EtherHCID 78922-MethylpentaneHCID 9346202-(Difluoromethoxy)aniline

生成物 1

HCID 178516461HCID 178516461、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-difluoromethoxyaniline (7.63 g) and the product from step a) were stirred in acetonitrile (100 ml) overnight. The solvent was removed by evaporation and the solid triturated with 4:1 isohexane/diethyl ether (200 ml) before filtering to give a light green solid. The solid was added portionwise to refluxing diphenylether (120 ml) and continued heating for a further 10 minutes before cooling. The solution was poured into isohexane (600 ml) and the solid filtered off to give the title compound (12.0 g).

後処理

  1. customThe solvent was removed by evaporation
  2. customthe solid triturated with 4:1 isohexane/diethyl ether (200 ml)
  3. filtrationbefore filtering
  4. customto give a light green solid
  5. additionThe solid was added portionwise
  6. temperaturecontinued heating for a further 10 minutes
  7. temperaturebefore cooling
  8. filtrationthe solid filtered off

出典と根拠

ORDレコード
ord-4cc948c9ffb34d069ef25ec8ec3f8d63
出典データセット
uspto-grants-2012_01
特許番号
US08093278B2

関連ノート

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