Binap, (A+-)- → (2S)-4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}-2-pentanol

反応式

[NH2:1][CH2:2][C@@:3]([OH:21])([CH2:8][C:9]([C:12]1[C:20]2[O:19][CH2:18][CH2:17][C:16]=2[CH:15]=[CH:14][CH:13]=1)([CH3:11])[CH3:10])[C:4]([F:7])([F:6])[F:5].Br[C:23]1[CH:31]=[C:30]([CH3:32])[CH:29]=[C:28]2[C:24]=1[CH:25]=[N:26][N:27]2[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1.CC(C)([O-])C.[Na+]>C1(C)C=CC=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[O:19]1[C:20]2[C:12]([C:9]([CH3:11])([CH3:10])[CH2:8][C@@:3]([CH2:2][NH:1][C:23]3[CH:31]=[C:30]([CH3:32])[CH:29]=[C:28]4[C:24]=3[CH:25]=[N:26][N:27]4[C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)([OH:21])[C:4]([F:6])([F:7])[F:5])=[CH:13][CH:14]=[CH:15][C:16]=2[CH2:17][CH2:18]1