Tetrahydrofuran → HCID 57912422、化合物

HRID 418870ノート

反応式

HRID 418870 の反応式
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:16][C:15]3[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=3[O:13][CH:12]=2)=[CH:7][CH:6]=1)(=O)C.C1COCC1.C([O-])([O-])=O.[K+].[K+]>CO>[O:16]1[C:11]([C:8]2[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=2)=[CH:12][O:13][C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]1=2

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 11430Potassium CarbonateHCID 57912410HCID 57912410、化合物

生成物 1

HCID 57912422HCID 57912422、化合物収率 77.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 4-(benzo[b][1,4]dioxin-2-yl)phenyl acetate (270 mg, 1.0 mmol) in MeOH:THF (5 mL: 3 mL) and K2CO3 (167 mg, 1.2 mmol) was stirred for 30 min at rt. The solvent was removed under reduced pressure and water was added. The solution was neutralized by dilute HCl and the solid was isolated by filtration, washed well with water and dried to give 175 mg of 4-(benzo[b][1,4]dioxin-2-yl)phenol (77%). MS (ES) m/z: 225.97 (M), 224.93 (M−1); Mp. 137-140° C.

後処理

  1. customThe solvent was removed under reduced pressure and water
  2. additionwas added
  3. customthe solid was isolated by filtration
  4. washwashed well with water
  5. customdried

出典と根拠

ORDレコード
ord-3b096b12d41b46a097f66f621040daa8
出典データセット
uspto-grants-2012_01
特許番号
US08093273B2

反応ノート

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