Chlorosulfonic acid → HCID 58016189、化合物

HRID 41915

反応式

HRID 41915 の反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][CH2:14][Br:15])[CH:8]=1>>[Br:6][C:7]1[CH:12]=[CH:11][C:10]([S:2]([Cl:1])(=[O:5])=[O:3])=[C:9]([CH2:13][CH2:14][Br:15])[CH:8]=1

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 143612163-Bromophenethyl bromide

生成物 1

HCID 58016189HCID 58016189、化合物

反応条件

温度
0 °C

実験手順

Chlorosulfonic acid (17 mL) was added dropwise to 1-bromo-3-(2-bromo-ethyl)-benzene (5 g, 19 mmol) at 0° C. The mixture was stirred at 0° C. for 1 h then an additional 3 h at rt. The mixture was poured into an ice-water slowly and extracted with methylene chloride, and the combined organic layers were evaporated under reduced pressure to give 4.3 g of crude 4-Bromo-2-(2-bromo-ethyl)-benzenesulfonyl chloride which was used directly for next reaction. MS (ESI) 342.9 (M−Cl+OH)−.

後処理

  1. customan additional 3 h
  2. customat rt
  3. extractionextracted with methylene chloride
  4. customthe combined organic layers were evaporated under reduced pressure

出典と根拠

ORDレコード
ord-061a48ffc3df4d7fa01f9c3488afd563
出典データセット
uspto-grants-2013_09
特許番号
US08536166B2

関連ノート

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