反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=O)[CH2:7][CH2:6]2.Cl.[N:16]1[O:17][N:18]=[C:19]2[CH:24]=[C:23]([CH2:25][O:26][NH2:27])[CH:22]=[CH:21][C:20]=12.N1C=CC=CC=1.[N+](C1C=CC(CO/N=C2\CCCC3C\2=CC(OC)=C(OC)C=3)=CC=1)([O-])=O>C(O)C.C(OCC)(=O)C.CCCCCC>[N:16]1[O:17][N:18]=[C:19]2[CH:24]=[C:23]([CH2:25][O:26]/[N:27]=[C:8]3\[CH2:7][CH2:6][C:5]4[C:9]\3=[CH:10][C:11]([O:12][CH3:13])=[C:3]([O:2][CH3:1])[CH:4]=4)[CH:22]=[CH:21][C:20]=12参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
5,6-Dimethoxy-1-indanone (38 mg, 0.19 mmol) was subjected to reaction with O-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)hydroxylamine hydrochloride (39 mg, 0.19 mmol) in ethanol (2 mL) and pyridine (0.2 mL, 2.58 mmol) under the same conditions as described for (E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one O-4-nitrobenzyl oxime. Subjection of the material obtained on work up to flash chromatography (3:7 v/v ethyl acetate/hexane elution) afforded the title compound as off-white crystals (55 mg, 82%), m.p. 163-166° C., Rf 0.4.
出典と根拠
- ORDレコード
- ord-79490ee6dbb0457fbbbf3dc97b5fd167
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536157B2
関連ノート
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