1-[2-Ethyl-5-(ethyloxy)-4-nitrophenyl]-4-[2-(methylsulfonyl)ethyl]piperazine → 5-Ethyl-2-(methyloxy)-4-{4-[2-(methylsulfonyl)ethyl]-1-piperazinyl}aniline

HRID 419608ノート

反応式

HRID 419608 の反応式
[CH2:1]([C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[C:6]([O:12][CH2:13]C)=[CH:5][C:4]=1[N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH2:17][CH2:16]1)[CH3:2]>CCOC(C)=O.CO.[Pt]>[CH2:1]([C:3]1[C:4]([N:15]2[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH2:19][CH2:20]2)=[CH:5][C:6]([O:12][CH3:13])=[C:7]([CH:8]=1)[NH2:9])[CH3:2]

参加物

5

反応物 1

HCID 594526601-[2-Ethyl-5-(ethyloxy)-4-nitrophenyl]-4-[2-(methylsulfonyl)ethyl]piperazine

生成物 1

HCID 594529565-Ethyl-2-(methyloxy)-4-{4-[2-(methylsulfonyl)ethyl]-1-piperazinyl}aniline

試薬・触媒・溶媒 3

HCID 23939Platinum触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

1-[2-Ethyl-5-(ethyloxy)-4-nitrophenyl]-4-[2-(methylsulfonyl)ethyl]piperazine (0.63 g, 1.6 mmol) was taken up in EtOAc (30 mL) and MeOH (5 mL). The catalyst, 5% sulfided platinum on carbon (0.25 g) was added. The reaction was placed under 1 atm of H2 gas and was allowed to stir at rt overnight. The catalyst was filtered off and the filtrate was concentrated in vacuo to give the title compound without further purification (0.55 g, 1.5 mmol, 91%). MS (ESI) m/z=356 [M+H]+.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-04146842935a441db5883fd13208e7f1
出典データセット
uspto-grants-2012_01
特許番号
US08093239B2

反応ノート

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