Oxalyl chloride → (S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate

HRID 419769ノート

反応式

HRID 419769 の反応式
[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@@:12]1([CH3:19])[C:16](O)=[O:17])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:23])=O>ClCCl.CN(C)C=O>[Cl:23][C:16]([C@:12]1([CH3:19])[CH2:13][CH2:14][CH2:15][N:11]1[C:9]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10])=[O:17]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 18604408HCID 18604408、化合物

生成物 1

HCID 86643491(S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of (S)-1-(benzyloxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid (1.50 g) in dichloromethane (30 mL) was treated with oxalyl chloride (0.65 mL) and 3 drops of N,N-dimethylformamide at ambient temperature for 1.5 hours. The mixture was concentrated and the crude material used in the next step without further purification.

後処理

  1. concentrationThe mixture was concentrated
  2. customthe crude material used in the next step without further purification

出典と根拠

ORDレコード
ord-377d50e1d6664017ba4a218ebd63499c
出典データセット
uspto-grants-2012_01
特許番号
US08093396B2

反応ノート

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