5-Nitro-2,3-diphenylpyridine → 5,6-Diphenylpyridin-3-amine
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][CH:9]=1)([O-])=O>CO.[Pd]>[C:16]1([C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[N:8][C:7]=2[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1参加物
4
実験手順
A mixture of 5-nitro-2,3-diphenylpyridine (0.74 mmol, 0.21 g) and Pd/C 10% (0.02 g) in methanol (5 ml) was stirred for 16 hours under hydrogen atmosphere. The catalyst was filtered off and the solid thoughtfully washed with methanol. The solid residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 0.14 g (74% of yield) of the expected product.
後処理
- filtrationThe catalyst was filtered off
- washthe solid thoughtfully washed with methanol
- customThe solid residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate
- custommixtures affording
出典と根拠
- ORDレコード
- ord-11f155da721a4d2686ce16e3395a406e
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536165B2
反応ノート
読み込み中…