Ammonium Chloride → 4-(Thiazolo[4,5-c]pyridin-2-yl)benzenamine
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][C:12]3[CH:17]=[CH:16][N:15]=[CH:14][C:13]=3[N:18]=2)=[CH:6][CH:5]=1)([O-])=O.[NH4+].[Cl-]>CO.O.[Fe]>[S:11]1[C:12]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[N:18]=[C:10]1[C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1参加物
5
実験手順
2-(4-nitrophenyl)thiazolo[4,5-c]pyridine (2.57 g, 0.01 mol), iron powder (2.8 g, 0.05 mmol) and NH4Cl (4.32 g, 0.08 mol) were refluxed in CH3OH/H2O (4:1, 200 mL) for 6 h. The mixture was filtered and the filtrate was evaporated in vacuo. The residue was washed with water (30 ml) to give 4-(thiazolo[4,5-c]pyridin-2-yl)benzenamine as a white solid (1.37 g, Yield: 60%).
後処理
- filtrationThe mixture was filtered
- customthe filtrate was evaporated in vacuo
- washThe residue was washed with water (30 ml)
出典と根拠
- ORDレコード
- ord-335223bc2bc9483597ed644dd70f891a
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08093401B2
反応ノート
読み込み中…