2-(3-Methoxyphenyl)-5-nitro-3-phenylpyridine → 6-(3-Methoxyphenyl)-5-phenylpyridin-3-amine

HRID 41997ノート

反応式

HRID 41997 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:13][C:12]([N+:21]([O-])=O)=[CH:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[CH:11][C:12]([NH2:21])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 1

HCID 673943592-(3-Methoxyphenyl)-5-nitro-3-phenylpyridine

生成物 1

HCID 584158776-(3-Methoxyphenyl)-5-phenylpyridin-3-amine収率 69%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 2-(3-methoxyphenyl)-5-nitro-3-phenylpyridine (0.84 mmol, 0.257 g) and Pd/C 10% (0.08 mmol, 0.009 g) in ethanol (5 ml) was stirred for 16 hours under hydrogen atmosphere. The catalyst was filtered off and the solid thoughtfully washed with warm ethanol. The filtrate was evaporated and the crude was purified by chromatography over SiO2 eluting with DCM/methanol mixtures and affording 0.160 g (yield 69%) of the expected product.

後処理

  1. filtrationThe catalyst was filtered off
  2. washthe solid thoughtfully washed with warm ethanol
  3. customThe filtrate was evaporated
  4. customthe crude was purified by chromatography over SiO2 eluting with DCM/methanol mixtures

出典と根拠

ORDレコード
ord-b6ed7be95b84411ca165bbe6e28bda04
出典データセット
uspto-grants-2013_09
特許番号
US08536165B2

反応ノート

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