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Potassium Carbonate → 1,1-Dimethylethyl N-[(1-ethynylcyclopropyl)sulfonyl]carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1108658-38-3 | HCID 57816679 | — |
| 反応物 | HCID 178502985 | HCID 178502985 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1,1-Dimethylethyl N-[(1-ethynylcyclopropyl)sulfonyl]carbamate | HCID 57816689 | 85% |
反応手順
To a stirred solution of compound 80 (230 mg, 0.92 mmol) in MeOH (5 mL) at 0° C. was added K2CO3 (255 mg, 1.84 mmol), and Ohira-Bestmann reagent (215 g, 1.10 mmol) (Tetr. Lett. 2008, 49, 4454). The mixture was stirred at room temperature for 16 hrs and was concentrated under reduced pressure. Water, EtOAc, and citric acid were added to bring pH to 4-5. Organics were dried over Na2SO4, filtered, and concentrated under reduced pressure to yield compound 81 in 85% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08093379B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-50656435da35495c8fb7a297723df239 |
| 出典メモ | uspto-grants-2012_01 |