Trifluoroacetic acid → 1-Ethynylcyclopropane-1-sulfonamide
反応式
C([NH:8][S:9]([C:12]1([C:15]#[CH:16])[CH2:14][CH2:13]1)(=[O:11])=[O:10])(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:15]([C:12]1([S:9]([NH2:8])(=[O:11])=[O:10])[CH2:14][CH2:13]1)#[CH:16]参加物
4
実験手順
A mixture of compound 81 (200 mg, 0.81 mmol) and TFA (0.3 mL) in DCM (5 mL) was stirred at room temperature for 16 hrs. The reaction mixture was concentrated under reduced pressure and the crude material was purified by chromatography on silica gel (MeOH/DCM) to yield compound 82 in 70% yield.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe crude material was purified by chromatography on silica gel (MeOH/DCM)
出典と根拠
- ORDレコード
- ord-b1f34fdfd95b4beea33d28b680277221
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08093379B2
反応ノート
読み込み中…