Methylamine → ([2-(Methylamino)ethyl]sulfonyl)benzene
反応式
Cl[CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5].[CH3:13][NH2:14]>C(#N)C>[CH3:13][NH:14][CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5]参加物
4
実験手順
A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.
後処理
- customThe solvent is removed in vacuo
- customthe residue is partitioned between methylene chloride and dilute sodium hydroxide
- extractionThe methylene chloride solution is extracted with dilute sulfuric acid
- extractionThe acidic extract
- extractionthe basic solution is extracted with methylene chloride
- dry with materialThe methylene chloride solution is dried over magnesium sulfate
- customthe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-ae4c77ae86b04fcaa9012d4cce7a5a3a
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04724235
反応ノート
読み込み中…