Anthranilic Acid → Ethyl 2-aminobenzoate

HRID 42036

反応式

HRID 42036 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH2:16](O)[CH3:17]>>[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]

参加物

4

反応物 3

HCID 227Anthranilic AcidHCID 702EthanolHCID 1118Sulfuric Acid

生成物 1

HCID 6877Ethyl 2-aminobenzoate収率 78%

実験手順

To a solution of 2-aminobenzoic acid (7.29 mmol, 1.0 g) in ethanol (20 ml), H2SO4 (45 mmol, 2.5 ml) was added and the mixture was refluxed for 20 hours. The solvent was evaporated and the crude residue was dissolved in water. The solution neutralised with 6N NaOH aqueous solution and extracted with CHCl3. The organic phase was evaporated affording 0.939 g (yield 78%) of the expected product.

後処理

  1. temperaturethe mixture was refluxed for 20 hours
  2. customThe solvent was evaporated
  3. dissolutionthe crude residue was dissolved in water
  4. extractionextracted with CHCl3
  5. customThe organic phase was evaporated

出典と根拠

ORDレコード
ord-4b37735ad9534962a4502eed81159ae0
出典データセット
uspto-grants-2013_09
特許番号
US08536165B2

関連ノート

読み込み中…