Anthranilic Acid → Ethyl 2-aminobenzoate
反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH2:16](O)[CH3:17]>>[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]参加物
4
実験手順
To a solution of 2-aminobenzoic acid (7.29 mmol, 1.0 g) in ethanol (20 ml), H2SO4 (45 mmol, 2.5 ml) was added and the mixture was refluxed for 20 hours. The solvent was evaporated and the crude residue was dissolved in water. The solution neutralised with 6N NaOH aqueous solution and extracted with CHCl3. The organic phase was evaporated affording 0.939 g (yield 78%) of the expected product.
後処理
- temperaturethe mixture was refluxed for 20 hours
- customThe solvent was evaporated
- dissolutionthe crude residue was dissolved in water
- extractionextracted with CHCl3
- customThe organic phase was evaporated
出典と根拠
- ORDレコード
- ord-4b37735ad9534962a4502eed81159ae0
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536165B2
反応ノート
読み込み中…