2-Bromo-5-iodo-3-methylpyridine → Ethyl 2-(6-bromo-5-methylpyridin-3-ylamino)-5-methylbenzoate

HRID 42042

反応式

HRID 42042 の反応式
[NH2:1][C:2]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[Br:14][C:15]1[C:20]([CH3:21])=[CH:19][C:18](I)=[CH:17][N:16]=1>>[Br:14][C:15]1[N:16]=[CH:17][C:18]([NH:1][C:2]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:19][C:20]=1[CH3:21]

参加物

3

反応物 2

HCID 101086802-Bromo-5-iodo-3-methylpyridineHCID 12327280Ethyl 2-amino-5-methylbenzoate

生成物 1

HCID 86657258Ethyl 2-(6-bromo-5-methylpyridin-3-ylamino)-5-methylbenzoate収率 25%

実験手順

Obtained (0.050 g, yield 25%) following the procedure described in Intermediate 16 starting with ethyl 2-amino-5-methylbenzoate (0.56 mmol, 0.100 g) and 2-bromo-5-iodo-3-methylpyridine (1.0 mmol, 0.166 g).

後処理

  1. customObtained (0.050 g, yield 25%)

出典と根拠

ORDレコード
ord-fd08ee6b90a440f8a547e6b85ab5b924
出典データセット
uspto-grants-2013_09
特許番号
US08536165B2

関連ノート

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