Methyl 2-(6-(benzyloxy)-5-phenylpyridin-3-ylamino)-5-cyclopropylbenzoate → HCID 178524103、化合物
反応式
C([O:8][C:9]1[N:14]=[CH:13][C:12]([NH:15][C:16]2[CH:25]=[CH:24][C:23]([CH:26]3[CH2:28][CH2:27]3)=[CH:22][C:17]=2[C:18]([O:20]C)=[O:19])=[CH:11][C:10]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[CH:26]1([C:23]2[CH:24]=[CH:25][C:16]([NH:15][C:12]3[CH:13]=[N:14][C:9]([OH:8])=[C:10]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH:11]=3)=[C:17]([CH:22]=2)[C:18]([OH:20])=[O:19])[CH2:27][CH2:28]1参加物
3
実験手順
A solution of methyl 2-(6-(benzyloxy)-5-phenylpyridin-3-ylamino)-5-cyclopropylbenzoate (0.34 mmol, 0.155 g) in TFA (1.3 ml) was stirred at 45° C. for 30 minutes. The solvent was removed under reduced pressure. The crude mixture was solved in ethanol (2 ml), 2N aqueous NaOH were added and stirred at room temperature for 16 hours. The solvent was removed and the crude was neutralised with 2N aqueous HCl and extracted with CHCl3. The crude mixture was purified by ionic exchange through a SCX cartridge affording 0.060 g (50% of yield).
後処理
- customThe solvent was removed under reduced pressure