Methanol → 5-Amino-1,2-dihydroquinolin-2-one

HRID 420620

反応式

HRID 420620 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](=[O:14])[NH:9]2)([O-])=O.CO.[H][H]>C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](=[O:14])[NH:9]2

参加物

6

反応物 3

HCID 887MethanolHCID 2437765-Nitro-1,2-dihydroquinolin-2-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 157190785-Amino-1,2-dihydroquinolin-2-one収率 100.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

4.5 g of 5-nitroquinolin-2(1H)-one (Chem. Pharm. Bull., 29, 651 (1981)) is hydrogenated in 200 ml of ethyl acetate and 500 ml of methanol in the presence of 450 mg of palladium on activated carbon as a catalyst under normal pressure with hydrogen until the reaction is completed. The catalyst is removed by filtration through diatomaceous earth, and the reaction solution is concentrated by evaporation in a vacuum. 3.8 g of the title compound is obtained as a yellow solid.

後処理

  1. customThe catalyst is removed by filtration through diatomaceous earth
  2. concentrationthe reaction solution is concentrated by evaporation in a vacuum

出典と根拠

ORDレコード
ord-9a77856c67614cb68cbd1c4187a002ae
出典データセット
uspto-grants-2012_01
特許番号
US08097627B2

関連ノート

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