Hydrochloric Acid → 2-Methoxy-5-sulfamoylbenzoic acid

HRID 421078ノート

反応式

HRID 421078 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>CO>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 118390Methyl 5-sulfamoyl-o-anisate

生成物 1

HCID 896012-Methoxy-5-sulfamoylbenzoic acid収率 98.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 2-methoxy-5-sulfamoylbenzoate (4.91 g, 20 mmol) was dissolved in methanol (30 mL). 2 N aqueous sodium hydroxide (30 mL, 60 mmol) was added, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into 2 N hydrochloric acid, and the separated solid was filtered to give the title compound (4.55 g, 98.3%) as a white solid.

後処理

  1. filtrationthe separated solid was filtered

出典と根拠

ORDレコード
ord-fc1ae7f914b24249924e23366f7876fa
出典データセット
uspto-grants-2012_01
特許番号
US08097759B2

反応ノート

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