2-Amino-6-nitrobenzothiazole → 2,6-Benzothiazolediamine

HRID 421291

反応式

HRID 421291 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:5]=2[N:6]=1.[H][H]>CO.[Pd]>[S:3]1[C:4]2[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[NH2:1]

参加物

5

反応物 2

HCID 227042-Amino-6-nitrobenzothiazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 215042,6-Benzothiazolediamine収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-Amino-6-nitrobenzothiazole (1.0 g, 5.12 mmol) was dissolved in 100 ml of MeOH and palladium on activated carbon (10%, 545 mg, 0.51 mmol) was added. The reaction mixture was hydrogenated using hydrogen at RT (3 bar H2) for 2.5 h. The mixture was filtered, the solvent was removed under reduced pressure and the residue was purified using silica gel chromatography (ethyl acetate:n-heptane 1:2). 0.81 g (yield: 96%) of the purified title compound was obtained.

後処理

  1. customat RT
  2. customfor 2.5 h
  3. filtrationThe mixture was filtered
  4. customthe solvent was removed under reduced pressure
  5. customthe residue was purified
  6. custom0.81 g (yield: 96%) of the purified title compound
  7. customwas obtained

出典と根拠

ORDレコード
ord-33d67ecb6f9447b3a700208fec01f7c7
出典データセット
uspto-grants-2012_01
特許番号
US08097758B2

関連ノート

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