Nitric Acid → Quetiapine Nitrate

HRID 421567

反応式

HRID 421567 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[N+:28]([O-:31])([OH:30])=[O:29]>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[N+:28]([O-:31])([O-:30])=[O:29]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 5002Quetiapine

生成物 1

HCID 86647094Quetiapine Nitrate収率 80.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of 68 to 72% nitric acid (0.7 g) at 20 to 25° C. The resulting precipitated solid was stirred for 1 hour. The precipitated product was collected by filtration, washed with acetone (15 ml) and dried to give the title compound as white powder (4.0 g).

後処理

  1. customThe resulting precipitated solid
  2. filtrationThe precipitated product was collected by filtration
  3. washwashed with acetone (15 ml)
  4. customdried

出典と根拠

ORDレコード
ord-bf4fd07b135d4045b967766573be7751
出典データセット
uspto-grants-2012_01
特許番号
US08101597B2

関連ノート

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