Quetiapine → HCID 131729402、化合物

HRID 421570

反応式

HRID 421570 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]1([CH3:55])[CH:33]=[CH:32][C:31]([C:34]([C@@:36]([C:52]([OH:54])=[O:53])([OH:51])[C@@:37]([C:42]([C:44]2[CH:49]=[CH:48][C:47]([CH3:50])=[CH:46][CH:45]=2)=[O:43])([OH:41])[C:38]([OH:40])=[O:39])=[O:35])=[CH:30][CH:29]=1>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]1([CH3:55])[CH:33]=[CH:32][C:31]([C:34]([C@@:36]([C:52]([O-:54])=[O:53])([OH:51])[C@@:37]([C:42]([C:44]2[CH:45]=[CH:46][C:47]([CH3:50])=[CH:48][CH:49]=2)=[O:43])([OH:41])[C:38]([O-:40])=[O:39])=[O:35])=[CH:30][CH:29]=1

参加物

4

反応物 2

HCID 5002QuetiapineHCID 29414711Di-para-toluoyl-L-tartaric acid

生成物 1

HCID 131729402HCID 131729402、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Quetiapine free base (3.0 g) was dissolved in acetone (30 ml) at room temperature. To this solution was added di-p-toluoyl-L-tartaric acid (1.52 g) at 30 to 35° C. The resulting mass heated to reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.62 g).

後処理

  1. temperatureThe resulting mass heated
  2. temperatureto reflux
  3. temperaturemaintained for 30 minutes
  4. distillationThis was followed by the distillation of acetone
  5. customobtained solid
  6. customwas further dried under vacuum

出典と根拠

ORDレコード
ord-06dbf6660c6847878637dcbfbbfbcc4f
出典データセット
uspto-grants-2012_01
特許番号
US08101597B2

関連ノート

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