化工社化工社 化学情報印刷レポート · 研究参考用
Quetiapine → Quetiapine di-p-toluoyl-L-(+)-tartrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Quetiapine | HCID 5002 | — |
| 反応物 | Di-para-toluoyl-L-tartaric acid | HCID 29414711 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Quetiapine di-p-toluoyl-L-(+)-tartrate | HCID 131729402 | — |
反応手順
Quetiapine free base (3.0 g) was dissolved in acetone (30 ml) at room temperature. To this solution was added di-p-toluoyl-L-tartaric acid (1.52 g) at 30 to 35° C. The resulting mass heated to reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.62 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08101597B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-06dbf6660c6847878637dcbfbbfbcc4f |
| 出典メモ | uspto-grants-2012_01 |