Methyl(4S)-5-azido-4-[(tert-butoxy)carbonylamino]pentanoate → (S)-tert-butyl 6-oxopiperidin-3-ylcarbamate
反応式
[N:1]([CH2:4][C@@H:5]([NH:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:6][CH2:7][C:8](OC)=[O:9])=[N+]=[N-].[H][H]>CO.[Pd]>[O:9]=[C:8]1[NH:1][CH2:4][C@@H:5]([NH:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:6][CH2:7]1参加物
5
実験手順
Methyl (4S)-5-azido-4-[(tert-butoxy)carbonylamino]pentanoate (3.9 mmol, 1.07 g) was dissolved in methanol (10 mL), and 10% palladium on carbon (0.1 g) was added. The reaction was stirred overnight under 1 atm of hydrogen. The reaction was filtered and the solvent was removed in vacuo to yield the title compound (0.83 g, 99% yield). ES-MS: 215 (M+1).
後処理
- filtrationThe reaction was filtered
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-42cecedbc59b4e93b44162c36463943b
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101588B2
反応ノート
読み込み中…