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HRID 421678作成日：2026年10月27日

4-(4-Methylpiperazin-1-yl)benzoic acid → N-(4-chloro-3-(4-(4-methylpiperazin-1-yl)benzamido)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide

https://huagongshe.com/reaction/421678

反応式

関与物質

役割名称HCID仕込み量
反応物4-(4-Methylpiperazin-1-yl)benzoic acidHCID 736532—
反応物N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamideHCID 16730560—
生成物N-(4-chloro-3-(4-(4-methylpiperazin-1-yl)benzamido)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamideHCID 16730714—

反応手順

N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.15 mmol) was used in general procedure 2 with 4-(4-methylpiperazin-1-yl)benzoic acid (0.167 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(4-(4-methylpiperazin-1-yl)benzamido)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide. MS (Q1) 532.0 (M)+

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08101610B2
出典データセットuspto-grants-2012_01
ORD IDord-a3bfcaa7085843a3bb302caec3b4a782
出典メモuspto-grants-2012_01