3-(Diethylamino)propyl isothiocyanate → N'-[3-(Diethylamino)propyl]-N-(1-methylethyl)-N-[2-(phenylsulfonyl)ethyl]thiourea

HRID 4218

反応式

HRID 4218 の反応式
[C:1]1([S:7]([CH2:10][CH2:11][NH:12][CH:13]([CH3:15])[CH3:14])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([N:18]([CH2:21][CH2:22][CH2:23][N:24]=[C:25]=[S:26])[CH2:19][CH3:20])[CH3:17]>C(#N)C>[CH2:19]([N:18]([CH2:16][CH3:17])[CH2:21][CH2:22][CH2:23][NH:24][C:25](=[S:26])[N:12]([CH:13]([CH3:15])[CH3:14])[CH2:11][CH2:10][S:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)(=[O:8])=[O:9])[CH3:20]

参加物

4

反応物 2

HCID 27582403-(Diethylamino)propyl isothiocyanateHCID 13655034N-(2-phenylsulfonylethyl)-2-propanamine

生成物 1

HCID 13655152N'-[3-(Diethylamino)propyl]-N-(1-methylethyl)-N-[2-(phenylsulfonyl)ethyl]thiourea収率 76.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 5.0 g (0.022 mole) of N-[2-(phenylsulfonyl)ethyl]-2-propanamine and 4.30 g (0.025 mole) of 3-(N,N-diethylamino)propylisothiocyanate in 400 ml of acetonitrile was refluxed for 16 hr. The solvent was removed in vacuo and the residue was dissolved in ether. The solution was extracted with three portions of water and was dried over magnesium sulfate. The volume of the ether solution was reduced to 200 ml, and hexane was added until the solution became slightly cloudy. A white solid precipitated to give 6.76 g (76.9%) of white crystalline solid, m.p. 120°-121° C.

後処理

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in ether
  3. extractionThe solution was extracted with three portions of water
  4. dry with materialwas dried over magnesium sulfate
  5. additionwas added until the solution
  6. customA white solid precipitated

出典と根拠

ORDレコード
ord-83cce351f7ce40fbbfb94ec6344ceae4
出典データセット
uspto-grants-1988_02
特許番号
US04724235

関連ノート

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