Trifluoroacetic acid → Trifluoroacetic acid

HRID 42183ノート

反応式

HRID 42183 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[N:7][C:8]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)=[N:9][CH:10]=1)=[O:4].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:7][CH:6]=1)=[O:4].[C:26]([OH:28])([C:25]([F:30])([F:29])[F:24])=[O:27]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 59240679Methyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylate

生成物 2

HCID 6422Trifluoroacetic acid収率 262.7%HCID 57471612Methyl 2-(piperazin-1-yl)pyrimidine-5-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-(4-tert-Butoxycarbonyl-piperazin-1-yl)-pyrimidine-5-carboxylic acid methyl ester (140 mg, 0.434 mmol) is dissolved in dichloromethane (3.0 mL) under N2. Trifluoroacetic acid (0.83 ml, 10.85 mmol) is added and the reaction mixture is stirred for 2 h. The reaction mixture is concentrated under reduced pressure and co-evaporated several times with dichloromethane. It is dried under high vacuum to afford the title compound as a TFA salt (130 mg, 90% yield).

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customIt is dried under high vacuum

出典と根拠

ORDレコード
ord-f0ad376f7fb445229dc8392f8c020b6f
出典データセット
uspto-grants-2013_09
特許番号
US08536168B2

反応ノート

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