反応式
[CH2:1]([N:3]([CH2:7][CH3:8])[CH2:4][CH2:5][NH2:6])[CH3:2].[C:9](N1C=CN=C1)(N1C=CN=C1)=[S:10].[C:21]1([S:27]([CH2:30][CH2:31][NH:32][CH:33]([CH3:35])[CH3:34])(=[O:29])=[O:28])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O1CCCC1>[CH2:1]([N:3]([CH2:7][CH3:8])[CH2:4][CH2:5][NH:6][C:9](=[S:10])[N:32]([CH:33]([CH3:35])[CH3:34])[CH2:31][CH2:30][S:27]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)(=[O:28])=[O:29])[CH3:2]参加物
5
実験手順
A mixture of 2.78 g (0.024 mole) of N,N-diethylethylenediamine and 4.82 g (0.027 mole) of 1,1'-thiocarbonyldiimidazole in 400 ml of tetrahydrofuran was stirred at room temperature for 1 hr. A solution of 5.00 g (0.022 mole) of N-[2-(phenylsulfonyl)ethyl]-2-propanamine in 100 ml of tetrahydrofuran was added, and the solution was refluxed for 48 hrs. The solvent was removed in vacuo and the residue was dissolved in 400 ml of a 50/50 mixture of methylene chloride and ether. The organic solution was extracted with water and was dried over magnesium sulfate. The solvent was removed in vacuo, and the residue was recrystallized from a mixture of methylene chloride-ether-hexane to give 5.95 g (72.5%) of pale yellow solid, m.p.81.5°-82.5° C.
後処理
- temperaturethe solution was refluxed for 48 hrs
- customThe solvent was removed in vacuo
- dissolutionthe residue was dissolved in 400 ml of a 50/50 mixture of methylene chloride and ether
- extractionThe organic solution was extracted with water
- dry with materialwas dried over magnesium sulfate
- customThe solvent was removed in vacuo
- customthe residue was recrystallized from a mixture of methylene chloride-ether-hexane
出典と根拠
- ORDレコード
- ord-00fb66882c6644f8a3f0fc09bf6d44fa
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04724235
関連ノート
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