Hydrochloric Acid → 3-Chloro-2-cyanobenzoic acid

HRID 421994ノート

反応式

HRID 421994 の反応式
C[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:11]#[N:12])[C:3]=1[Cl:13].[OH-].[Na+].Cl>CO>[Cl:13][C:3]1[C:4]([C:11]#[N:12])=[C:5]([CH:9]=[CH:10][CH:2]=1)[C:6]([OH:8])=[O:7]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66676571Methyl 3-chloro-2-cyanobenzoic acid

生成物 1

HCID 533972953-Chloro-2-cyanobenzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The mixture of 430 mg of methyl 3-chloro-2-cyanobenzoic acid obtained by the same manner as in U.S. Pat. No. 4,900,739, 22 ml of methanol and 2.5 ml of aqueous sodium hydroxide (1 mol/l) was stirring at room temperature for 2 hours. To the reaction mixture was added hydrochloride (5 mol/l) and was extracted with chloroform. The organic layer was washed with water and saturated brine, and then dried over magnesium sulfate. The organic layer was filtered and concentrated in vacuo to give the title compound.

後処理

  1. customobtained by the same manner as in U.S
  2. extractionwas extracted with chloroform
  3. washThe organic layer was washed with water and saturated brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationThe organic layer was filtered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-bdf338e722c146889b2ab6f5cf116b09
出典データセット
uspto-grants-2012_01
特許番号
US08101621B2

反応ノート

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