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Dimethylformamide → 3-(4-methyl-imidazol-1-yl)-N-[3-(2-oxo-2,3-dihydro-1H-indol-6-ylamino)-phenyl]-5-trifluoromethyl-benzamide

HRID 422036
ノート
印刷プレビュー

反応式

HRID 422036 の反応式
NC1C=C(C=CC=1)O[C:6]1[CH:14]=[C:13]2[C:9]([CH2:10][C:11](=[O:15])[NH:12]2)=[CH:8][CH:7]=1.Cl.C[N:21]1[CH2:26][CH2:25][N:24]([C:27]2[CH:28]=[C:29]([CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=2)[C:30]([OH:32])=O)[CH2:23]C1.C([N:43](CC)[CH:44]([CH3:46])[CH3:45])(C)C.CN(C(O[N:57]1N=N[C:59]2[CH:60]=CC=N[C:58]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH3:73]N(C=O)C>CCOC(C)=O>[CH3:73][C:26]1[N:21]=[CH:23][N:24]([C:27]2[CH:28]=[C:29]([CH:33]=[C:34]([C:36]([F:37])([F:38])[F:39])[CH:35]=2)[C:30]([NH:57][C:58]2[CH:59]=[CH:60][CH:45]=[C:44]([NH:43][C:6]3[CH:14]=[C:13]4[C:9]([CH2:10][C:11](=[O:15])[NH:12]4)=[CH:8][CH:7]=3)[CH:46]=2)=[O:32])[CH:25]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 5

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 467382893-(4-Methyl-piperazin-1-yl)-5-trifluoromethyl-benzoic acid hydrochlorideHCID 598043186-(3-Amino-phenoxy)-1,3-dihydro-indol-2-one

生成物 1

HCID 59804309
3-(4-methyl-imidazol-1-yl)-N-[3-(2-oxo-2,3-dihydro-1H-indol-6-ylamino)-phenyl]-5-trifluoromethyl-benzamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 6-(3-amino-phenoxy)-1,3-dihydro-indol-2-one (200 mg, 0.83 mmol) and 3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzoic acid hydrochloride (291 mg, 0.89 mmol) in DMF (10 mL) is added N,N-diisopropylethylamine (164 μL, 1 mmol) followed by addition of HATU (380 mg, 1 mmol). The mixture is stirred at ambient temperature overnight. The mixture is diluted with EtOAc and washed with 10% aq Na2S2O3 solution and brine. The organic layer is separated, dried over MgSO4, and concentrated. The crude (310 mg) was used in the next step without further purification. LC/MS: 511.2 (MH+).

後処理

  1. washwashed with 10% aq Na2S2O3 solution and brine
  2. customThe organic layer is separated
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated
  5. customThe crude (310 mg) was used in the next step without further purification

出典と根拠

ORDレコード
ord-9145b9933c9048a0b6eb2985d70b8338
出典データセット
uspto-grants-2012_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08101608B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート