Potassium Hydroxide → 4-(1-Oxo-indan-5-yloxy)-benzamide

HRID 422217

反応式

HRID 422217 の反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][C:12]3[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[OH-:20].[K+]>C(O)(C)(C)C>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][C:12]3[CH:19]=[CH:18][C:15]([C:16]([NH2:17])=[O:20])=[CH:14][CH:13]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 597506434-(1-Oxo-indan-5-yloxy)-benzonitrile

生成物 1

HCID 597506634-(1-Oxo-indan-5-yloxy)-benzamide収率 5.8%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

Combine 4-(1-Oxo-indan-5-yloxy)-benzonitrile (1.64 g, 6.58 mmol), tert-butyl alcohol (50 ml), and grounded KOH (1.85 g, 32.89 mmol) at room temperature under nitrogen atmosphere. Stir the reaction for 24 hours then concentrate under reduced pressure. Add Ethyl acetate to the reaction mixture and wash with brine. Dry the organic layer over Na2SO4. A yellow-mange solid precipitates out to afford 101.0 mg, 0.38 mmol (5.7% yield) of the title compound: No Characterization—Characterized by sequential reaction.

後処理

  1. customat room temperature
  2. customthe reaction for 24 hours
  3. concentrationthen concentrate under reduced pressure
  4. washAdd Ethyl acetate to the reaction mixture and wash with brine
  5. dry with materialDry the organic layer over Na2SO4
  6. customA yellow-mange solid precipitates out

出典と根拠

ORDレコード
ord-6f3198d2da994130a586221560d03f30
出典データセット
uspto-grants-2012_01
特許番号
US08101638B2

関連ノート

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