Sodium Azide → HCID 178505536、化合物
反応式
[N-:1]=[N+:2]=[N-:3].[Na+].[F:5][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[N+]([O-])=O)=[CH:8][CH:7]=1>CS(C)=O>[F:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:1]=[N:2][NH:3][CH:13]=2)=[CH:8][CH:7]=1参加物
4
実験手順
Sodium azide (4.28 g, 65.8 mmol) was added to a solution (E)-1-fluoro-4-(2-nitro-vinyl)-benzene (1.00 g, 5.98 mmol) in DMSO (50 mL), the solution was stirred at room temperature for 14 hours and the reaction mixture was poured onto water. The aqueous phase was extracted with AcOEt. The organic phase was washed with saturated solution of NaHCO3, brine, dried over MgSO4, filtered and evaporated to yield 300 mg (1.84 mmol, 31%) of 4-(4-fluoro-phenyl)-1H-[1,2,3]triazole.
後処理
- additionthe reaction mixture was poured onto water
- extractionThe aqueous phase was extracted with AcOEt
- washThe organic phase was washed with saturated solution of NaHCO3, brine
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-5dd571090d914aeabf9a745a6730e8f9
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101637B2
反応ノート
読み込み中…