Isopropylamine → 6-bromo-N-isopropylphthalazin-1-amine
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](Cl)=[N:7][N:6]=[CH:5]2.[CH:13]([NH2:16])([CH3:15])[CH3:14]>CN1C(=O)CCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([NH:16][CH:13]([CH3:15])[CH3:14])=[N:7][N:6]=[CH:5]2参加物
4
反応条件
- 温度
- 125 °C
実験手順
In a sealed glass tube, a mixture of 6-bromo-1-chlorophthalazine (18, 0.40 g, 1.64 mmol), isopropyl amine (0.420 mL, 4.92 mmol) in NMP (2.0 mL) was heated in a microwave at 125° C. for 15 minutes. The resulting brown mixture was loaded on a 40 g ISCO column (eluted with 35-100% EtOAc in Hexanes) and purified to provide the title compound a light yellow crystalline solid. MS (ESI, pos. ion) m/z: 266.9 (M+1).
後処理
- washThe resulting brown mixture was loaded on a 40 g ISCO column (eluted with 35-100% EtOAc in Hexanes)
- custompurified
出典と根拠
- ORDレコード
- ord-99c659fd76f54037a7781aa8fe19eb65
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101612B2
反応ノート
読み込み中…