Sodium Hydroxide → HCID 67360726、化合物

HRID 42292

反応式

HRID 42292 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16]CC)=[O:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:20]>C(O)C>[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]([O-:16])=[O:15])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:20]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 90423Ethyl 1-benzylpiperidine-4-carboxylate

生成物 1

HCID 67360726HCID 67360726、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution consisting of ethyl 1-benzylpiperidine-4-carboxylate (500 mg, 2.02 mmol) in ethanol (10 mL) was added 1 N sodium hydroxide (2.02 mL, 2.02 mmol) and the reaction mixture was stirred at room temperature overnight. Most of the ethanol was removed under reduced pressure and stirring was continued for six hours. Toluene was added to remove most of the water by azeotrope and the material was dried under high vacuum overnight to provide the title intermediate as a white solid.

後処理

  1. customMost of the ethanol was removed under reduced pressure
  2. stirringstirring
  3. waitwas continued for six hours
  4. additionToluene was added
  5. customto remove most of the water by azeotrope
  6. customthe material was dried under high vacuum overnight

出典と根拠

ORDレコード
ord-40dbbd8fd46b49eead2356f55fbcb971
出典データセット
uspto-grants-2013_09
特許番号
US08536185B2

関連ノート

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