Methanol → 3-Ethyl-5-fluoro-4-hydroxybenzoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([CH:10]=[CH2:11])[C:7]([OH:12])=[C:6]([F:13])[CH:5]=1.CO>C1COCC1.[C].[Pd]>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:5]=[C:6]([F:13])[C:7]([OH:12])=[C:8]([CH2:10][CH3:11])[CH:9]=1参加物
5
実験手順
A suspension of 3-fluoro-4-hydroxy-5-vinylbenzoic acid methyl ester (121 mg) and 10% palladium carbon (20 mg) in THF (1 mL)-methanol (1 mL) was hydrogenated at room temperature over night at medium pressure (3 kgf/cm2). The catalyst was filtered off through a Celite pad, and the filtrate was concentrated to give the title compound (121 mg).
後処理
- waitwas hydrogenated at room temperature over night at medium pressure (3 kgf/cm2)
- filtrationThe catalyst was filtered off through a Celite pad
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-efdb1a6677f24c2c8660e7c51eaf3ebb
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101774B2
反応ノート
読み込み中…