1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 3-[4-(5-{3-Chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl]propanoic acid

HRID 423368

反応式

HRID 423368 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH:12]([CH3:14])[CH3:13])[C:5]([OH:7])=O.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.O[NH:37][C:38](=[NH:55])[C:39]1[CH:47]=[CH:46][CH:45]=[C:44]2[C:40]=1[CH:41]=[CH:42][N:43]2[CH2:48][CH2:49][C:50]([O:52]CC)=[O:51]>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[O:7][N:55]=[C:38]([C:39]3[CH:47]=[CH:46][CH:45]=[C:44]4[C:40]=3[CH:41]=[CH:42][N:43]4[CH2:48][CH2:49][C:50]([OH:52])=[O:51])[N:37]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH:12]([CH3:14])[CH3:13]

参加物

6

反応物 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 225977283-Chloro-4-(propan-2-yloxy)benzoic acidHCID 178471833HCID 178471833、化合物

生成物 1

HCID 249863803-[4-(5-{3-Chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl]propanoic acid収率 19.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

3-chloro-4-[(1-methylethyl)oxy]benzoic acid (D4) (117 mg) was added to EDCI (114 mg) and HOBT (81 mg) dissolved in DMF (2.5 ml). This was stirred at RT for 10 minutes and then ethyl 3-{4-[(hydroxyamino)(imino)methyl]-1H-indol-1-yl}propanoate (D57) (150 mg) in DMF (2.5 ml) was added and stirring continued at RT for 2 hours then at 80° C. overnight. The reaction mixture was evaporated to dryness and extracted from H2O (25 ml) with EtOAc (2×25 ml). The combined organics were evaporated and treated with 2 M aq. NaOH (10 ml) and EtOH (10 ml), stirred at 50° C. for 2 hours then evaporated to remove the EtOH. The remaining solution was acidified, filtered and the precipitate washed with EtO/H2O then recrystallised from hot EtOH/H2O then from DMSO. Washing with Et2O and MeOH gave the title compound (46 mg) as a white solid. δH (d6-DMSO, 400 MHz): 1.37 (6H, d), 2.81 (2H, t), 4.50 (2H, t), 4.89 (1H, septet), 7.08 (1H, d), 7.35 (1H, apparent t), 7.46 (1H, d), 7.60 (1H, d), 7.81 (1H, d), 7.94 (1H, d), 8.15 (1H, dd), 8.23 (1H, d). MS (ES−): C22H2035ClN3O4 requires 425; found 424 (M−H+).

後処理

  1. stirringstirring
  2. waitcontinued at RT for 2 hours
  3. customat 80° C.
  4. customovernight
  5. customThe reaction mixture was evaporated to dryness
  6. extractionextracted from H2O (25 ml) with EtOAc (2×25 ml)
  7. customThe combined organics were evaporated
  8. additiontreated with 2 M aq. NaOH (10 ml) and EtOH (10 ml)
  9. stirringstirred at 50° C. for 2 hours
  10. customthen evaporated
  11. customto remove the EtOH
  12. filtrationfiltered
  13. washthe precipitate washed with EtO/H2O
  14. customthen recrystallised from hot EtOH/H2O
  15. washWashing with Et2O and MeOH

出典と根拠

ORDレコード
ord-780b7c725fa64b2b83933a6e7a8a6ae2
出典データセット
uspto-grants-2012_01
特許番号
US08101775B2

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