Ammonium Chloride → HCID 178462231、化合物

HRID 423708ノート

反応式

HRID 423708 の反応式
[OH:1][C@@H:2]([CH:4]1[CH2:9][CH2:8][N:7]([C:10]#[N:11])[CH2:6][CH2:5]1)[CH3:3].[Cl-].[NH4+].[N-:14]=[N+:15]=[N-:16].[Na+]>CN(C=O)C>[NH:14]1[C:10]([N:7]2[CH2:6][CH2:5][CH:4]([C@H:2]([OH:1])[CH3:3])[CH2:9][CH2:8]2)=[N:11][N:16]=[N:15]1

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 866387534-[(1R)-1-hydroxyethyl]-1-piperidinecarbonitrile

生成物 1

HCID 178462231HCID 178462231、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

A solution of 4-[(1R)-1-hydroxyethyl]-1-piperidinecarbonitrile (200 mg, 1.30 mmol) in DMF (5 mL) was treated with ammonium chloride (104 mg, 1.95 mmol) and sodium azide (126 mg, 1.95 mmol) at room temperature. The mixture was heated at 100° C. for 14 h. After allowing the mixture to cool, the solid was removed by filtration and washed with DMF. The filtrate was concentrated to give (1R)-1-[1-(1H-tetrazol-5-yl)-4-piperidinyl]ethanol, which was used without further purification.

後処理

  1. temperatureto cool
  2. customthe solid was removed by filtration
  3. washwashed with DMF
  4. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-f279832174a74669bc6b866c75fe8482
出典データセット
uspto-grants-2012_01
特許番号
US08101634B2

反応ノート

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