Potassium Formate → 4-(tert-Butyl)-3-methoxyaniline
反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:6]=1[O:14][CH3:15])([CH3:4])([CH3:3])[CH3:2].C([O-])=O.[K+]>CCO.O.[Pd]>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[O:14][CH3:15])([CH3:4])([CH3:2])[CH3:3]参加物
6
実験手順
To a refluxing solution of 1-tert-butyl-2-methoxy-4-nitrobenzene (82 mg, 0.4 mmol) in EtOH (2 mL) was added potassium formate (300 mg, 3.6 mmol) in water (1 mL), followed by 10% Pd—C (15 mg). The reaction mixture was refluxed for additional 60 min, cooled to room temperature and filtered through Celite. The filtrate was concentrated to dryness to give 4-tert-butyl-3-methoxyaniline (C-2) (52 mg, 72%) that was used without further purification. HPLC ret. time 2.29 min, 10-99% CH3CN, 5 min run; ESI-MS 180.0 m/z (MH+).
後処理
- temperatureThe reaction mixture was refluxed for additional 60 min
- filtrationfiltered through Celite
- concentrationThe filtrate was concentrated to dryness
出典と根拠
- ORDレコード
- ord-a11e7efe97f0412aa0fcce6bc98bec70
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101767B2
反応ノート
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