Ethylene Glycol → 3-(2-Hydroxyethyl)indolin-2-one

HRID 423866ノート

反応式

HRID 423866 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH2:11](O)[CH2:12][OH:13]>[Ni]>[OH:13][CH2:12][CH2:11][CH:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:10]

参加物

4

反応物 2

HCID 174Ethylene GlycolHCID 321710Oxindole

生成物 1

HCID 108992203-(2-Hydroxyethyl)indolin-2-one収率 70%

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

A stirring mixture of oxindole (5.7 g, 43 mmol) and Raney nickel (10 g) in ethane-1,2-diol (100 mL) was heated in an autoclave. After the reaction was complete, the mixture was filtered and the excess of diol was removed under vacuum. The residual oil was triturated with hexane to give 3-(2-hydroxy-ethyl)-1,3-dihydro-indol-2-one as a colorless crystalline solid (4.6 g, 70%).

後処理

  1. temperaturewas heated in an autoclave
  2. filtrationthe mixture was filtered
  3. customthe excess of diol was removed under vacuum
  4. customThe residual oil was triturated with hexane

出典と根拠

ORDレコード
ord-918ced9e4b794cf6b76aa2cd00e180c2
出典データセット
uspto-grants-2012_01
特許番号
US08101767B2

反応ノート

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