Hydrogen Bromide → Isoindolin-5-ol HCl
反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6]2.[BrH:12]>>[BrH:12].[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6]2参加物
3
実験手順
5-Methoxyisoindoline (8.34 g, 55.97 mmol) in 48% aqueous hydrobromic acid (100 ml) was stirred and held at reflux for 16 hours. Upon cooling to room temperature the solvent was removed in vacuo to afford 5-hydroxyisoindoline hydrobromide (1 1.32 g, 93%) as a tan solid. 1H NMR (DMSO-d6) 9.63 (1H, br s), 9.32 (2H, br s), 7.18 (1H, d), 6.79 (1H, d), 6.76 (1H, dd), 4.42 (2H, t), 4.38 (2H, t). MS: [M+H]+ 136.
後処理
- temperatureat reflux for 16 hours
- customwas removed in vacuo
出典と根拠
- ORDレコード
- ord-68a5ded7e8b04e0e9c1ad7d4d72869d8
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08101648B2
反応ノート
読み込み中…