1,2-Dichloroethane → 2-[(6-Bromohexanoyl)oxy]propyl acrylate

HRID 424304

反応式

HRID 424304 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].[C:10]([O:14][CH2:15][CH:16](O)[CH3:17])(=[O:13])[CH:11]=[CH2:12].C(Cl)CCl>C(Cl)Cl>[C:10]([O:14][CH2:15][CH:16]([O:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][Br:1])[CH3:17])(=[O:13])[CH:11]=[CH2:12]

参加物

5

反応物 3

HCID 111,2-DichloroethaneHCID 202106-Bromohexanoic acidHCID 612492-Hydroxypropyl acrylate

生成物 1

HCID 590050292-[(6-Bromohexanoyl)oxy]propyl acrylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

To a 0° C. cooled mixture of 6-bromohexanoic acid (9.89 g), 2-hydroxypropyl acrylate (6 g), in CH2Cl2 (30 ml), EDC (7.89 g) was added. After being stirred for 30 min the reaction mixture was diluted with additional 20 ml of CH2Cl2 and stirring was continued for 16 h at room temperature. It was then filtered over celite and the filtrate was evaporated to dryness. The obtained beige-yellow residue was purified by silica column chromatography to give nearly pure material as transparent oil.

後処理

  1. stirringstirring
  2. waitwas continued for 16 h at room temperature
  3. filtrationIt was then filtered over celite
  4. customthe filtrate was evaporated to dryness
  5. customThe obtained beige-yellow residue was purified by silica column chromatography
  6. customto give nearly pure material as transparent oil

出典と根拠

ORDレコード
ord-0e5407f232de4411a3a215497f6e7f7d
出典データセット
uspto-grants-2012_01
特許番号
US08105662B2

関連ノート

読み込み中…