Triethylamine → (2S)-2-Methylbutyl methanesulfonate

HRID 424306

反応式

HRID 424306 の反応式
[CH3:1][C@@H:2]([CH2:5][CH3:6])[CH2:3][OH:4].C(N(CC)CC)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>C1COCC1>[CH3:14][S:15]([O:4][CH2:3][C@@H:2]([CH3:1])[CH2:5][CH3:6])(=[O:17])=[O:16]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 2723602(S)-2-methyl-1-butanol

生成物 1

HCID 15698189(2S)-2-Methylbutyl methanesulfonate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
-10 °C

実験手順

To a −25° C. cooled solution of (2S)-2-methylbutan-1-ol (8.8 g) and triethylamine (30 ml) in THF (50 ml), a solution of methanesulfonyl chloride (1.14 g) in THF (10 ml) was drop wise added. After complete addition (15 min) the reaction mixture was further stirred for 2 h at −10° C. then for 30 min at 0° C. It was then filtered over celite and evaporated to dryness to give nearly pure (2S)-2-methylbutyl methanesulfonate as yellowish oil.

後処理

  1. additionwise added
  2. additionAfter complete addition (15 min) the reaction mixture
  3. waitfor 30 min at 0° C
  4. filtrationIt was then filtered over celite
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-43eae94417bb4729bb0435bdf9d95ecc
出典データセット
uspto-grants-2012_01
特許番号
US08105662B2

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