Propylamine → Benzeneacetic acid, 2,4-dinitro-, ethyl ester

HRID 424635ノート

反応式

HRID 424635 の反応式
C(N)CC.[N+:5]([C:8]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[CH:11]=[CH:10][C:9]=1[CH:17](C(=O)C)[C:18]([O:20][CH2:21][CH3:22])=[O:19])([O-:7])=[O:6]>C(Cl)(Cl)Cl>[N+:5]([C:8]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[CH:11]=[CH:10][C:9]=1[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])([O-:7])=[O:6]

参加物

4

反応物 2

HCID 7852PropylamineHCID 230687Ethyl 2-(2,4-dinitrophenyl)-3-oxobutanoate

生成物 1

HCID 106546Benzeneacetic acid, 2,4-dinitro-, ethyl ester収率 99%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Propan-1-amine (136 mmol) was added to a solution of ethyl 2-(2,4-dinitrophenyl)-3-oxobutanoate (135 mmol) in chloroform (500 mL). The reaction mixture was maintained for 12 h at rt and was concentrated. The residue was purified by chromatography 20/1 hexane/ethyl acetate to provide ethyl 2-(2,4-dinitrophenyl)acetate in 99% yield as a brown oil.

後処理

  1. concentrationwas concentrated
  2. customThe residue was purified by chromatography 20/1 hexane/ethyl acetate

出典と根拠

ORDレコード
ord-8744541de5c84a039d20a37835b6b355
出典データセット
uspto-grants-2012_01
特許番号
US08106066B2

反応ノート

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