Benzyl Bromide → 2-(Benzylthio)pyrimidine-4,6-diol

HRID 424657

反応式

HRID 424657 の反応式
[OH-].[Na+].[SH:3][C:4]1[N:9]=[C:8]([OH:10])[CH:7]=[C:6]([OH:11])[N:5]=1.[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C.O>[CH2:12]([S:3][C:4]1[N:9]=[C:8]([OH:10])[CH:7]=[C:6]([OH:11])[N:5]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 14798Sodium HydroxideHCID 178516656HCID 178516656、化合物

生成物 1

HCID 1785166522-(Benzylthio)pyrimidine-4,6-diol

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

反応条件

温度
60 °C

実験手順

A solution of sodium hydroxide (3.30 g) in ethanol/H2O (60 ml/60 ml) was added to 2-mercaptopyrimidine-4,6-diol (10.00 g) and the mixture stirred for 10 min. Benzyl bromide (13.45 g) was then added dropwise and the mixture heated at 60° C. for 2 h. The reaction was cooled to 0° C. for 1 h before the precipitate was filtered and washed with H2O (100 ml) and then dried in vacuo to afford the subtitle compound as a cream solid. Yield: 15.0 g.

後処理

  1. temperatureThe reaction was cooled to 0° C. for 1 h before the precipitate
  2. filtrationwas filtered
  3. washwashed with H2O (100 ml)
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-342092aec2cf48a0a856821b20271eb9
出典データセット
uspto-grants-2012_01
特許番号
US08106063B2

関連ノート

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