Thionyl Chloride → 2-(3-cyclopropyl-1,5-dihydro-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)-3,3,3-trifluoro-propanoic acid methyl ester

HRID 424910

反応式

HRID 424910 の反応式
[CH3:1][O:2][C:3](=[O:25])[C:4](O)([C:20]([F:23])([F:22])[F:21])[C:5]1[C:9](=[O:10])[N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:7][C:6]=1[CH:17]1[CH2:19][CH2:18]1.S(Cl)(Cl)=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3](=[O:25])[C:4](=[C:5]1[C:9](=[O:10])[N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:7]=[C:6]1[CH:17]1[CH2:18][CH2:19]1)[C:20]([F:22])([F:23])[F:21]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 667016013-cyclopropyl-alpha-hydroxy-2,5-dihydro-5-oxo-1-phenyl-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

生成物 1

HCID 667015552-(3-cyclopropyl-1,5-dihydro-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)-3,3,3-trifluoro-propanoic acid methyl ester

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a toluene solution (5 ml) of 3-cyclopropyl-α-hydroxy-2,5-dihydro-5-oxo-1-phenyl-α-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester (178 mg, 0.5 mmol), thionyl chloride (0.365 ml, 5.0 mmol) was added and the mixture was stirred under reflux for 3 hours. After concentrating the liquid reaction mixture under reduced pressure, the title compound was obtained as a reddish brown solid (169 mg).

後処理

  1. temperatureunder reflux for 3 hours
  2. concentrationAfter concentrating
  3. customthe liquid reaction mixture under reduced pressure

出典と根拠

ORDレコード
ord-d4b098cbad77498fbcb6b7e08164a5e6
出典データセット
uspto-grants-2012_01
特許番号
US08106086B2

関連ノート

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