Water → 2-(2,2,2-Trifluoroethoxy)ethyl p-toluenesulfonate

HRID 425069ノート

反応式

HRID 425069 の反応式
[F:1][C:2]([F:9])([F:8])[CH2:3][O:4][CH2:5][CH2:6][OH:7].[S:10](Cl)([C:13]1[CH:19]=[CH:18][C:16]([CH3:17])=[CH:15][CH:14]=1)(=[O:12])=[O:11].O>N1C=CC=CC=1>[CH3:17][C:16]1[CH:18]=[CH:19][C:13]([S:10]([O:7][CH2:6][CH2:5][O:4][CH2:3][C:2]([F:9])([F:8])[F:1])(=[O:12])=[O:11])=[CH:14][CH:15]=1

参加物

5

反応物 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 2558542-(2,2,2-Trifluoroethoxy)ethan-1-ol

生成物 1

HCID 220332952-(2,2,2-Trifluoroethoxy)ethyl p-toluenesulfonate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-(2,2,2-trifluoroethoxy)ethanol (intermediate BR) (12.7 g) was dissolved in anhydrous pyridine, then TsCl (1.3 eq) was added, and the mixture was stirred at room temperature for 16 h, after which TLC showed the reaction was complete. Then the mixture was poured into water, extracted with EA, washed with water and brine, and dried with anhydrous Na2SO4. The solvent was removed and the residue purified by column chromatography to obtain intermediate BS (0.3 g).

後処理

  1. extractionextracted with EA
  2. washwashed with water and brine
  3. dry with materialdried with anhydrous Na2SO4
  4. customThe solvent was removed
  5. customthe residue purified by column chromatography
  6. customto obtain intermediate BS (0.3 g)

出典と根拠

ORDレコード
ord-12b4bf431e7242bf8047ae71357f25ca
出典データセット
uspto-grants-2012_01
特許番号
US08106021B2

反応ノート

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