Sulfamic Acid → 2-Methoxy-5-methylsulfanilic acid

HRID 4252

反応式

HRID 4252 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:7]([CH3:10])=[CH:8][CH:9]=1)[NH2:6].[S:11](=[O:15])(=[O:14])([OH:13])N>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:6])[C:7]([CH3:10])=[CH:8][C:9]=1[S:11]([OH:15])(=[O:14])=[O:13]

参加物

4

反応物 2

HCID 5987Sulfamic AcidHCID 995005-Methoxy-o-toluidine

生成物 1

HCID 201521062-Methoxy-5-methylsulfanilic acid

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

23.1 g of 3-methoxy-6-methylaniline and 16.4 g of sulfamic acid were put into a 100 ml egg-plant type flask and the mixture was heated to temperature of from 150° to 160° C. and maintained thereat for 2 hours. Acetonitrile was added to the reaction mixture and the crystals thus deposited were collected. The crystals were dissolved in an aqueous solution of sodium hydroxide, the solution was filtered and acidified with hydrochloric acid, and the crystals thus deposited were collected by filtration.

後処理

  1. temperaturethe mixture was heated to temperature of from 150° to 160° C.
  2. temperaturemaintained
  3. customthe crystals thus deposited were collected
  4. dissolutionThe crystals were dissolved in an aqueous solution of sodium hydroxide
  5. filtrationthe solution was filtered
  6. filtrationthe crystals thus deposited were collected by filtration

出典と根拠

ORDレコード
ord-10a5e567c3634c778989865c564fb6c3
出典データセット
uspto-grants-1988_02
特許番号
US04725531

関連ノート

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