Sodium Hydroxide → HCID 178474713、化合物
反応式
[CH3:1][C:2]([CH3:33])([CH3:32])[CH2:3][C:4]1[N:5]=[C:6]([C:15](O)([CH3:30])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][N:24]=3)=[CH:19][CH:18]=2)[N:7](S(N(C)C)(=O)=O)[CH:8]=1.[OH-:34].[Na+].S(=O)(=O)(O)O.[C:41](#[N:43])[CH3:42]>>[CH3:32][C:2]([CH3:33])([CH3:1])[CH2:3][C:4]1[N:5]=[C:6]([C:15]([NH:43][C:41](=[O:34])[CH3:42])([CH3:30])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][N:24]=3)=[CH:19][CH:18]=2)[NH:7][CH:8]=1参加物
4
反応条件
- 温度
- 140 °C
実験手順
4-(2,2-dimethylpropyl)-2-{2-[4-(5-fluoropyridin-2-yl)phenyl]-1-hydroxy-1-methylethyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide (for synthesis see Example 15) (20 mg, 0.042 mmol) was dissolved in sulfuric acid/acetonitrile (1:1) (2 mL). After stirring at 140° C. overnight, the reaction mixture was cooled to ambient temperature, neutralized with aqueous sodium hydroxide and extracted with chloroform. The combined organic extracts were dried (magnesium sulfate), filtered, and concentrated in vacuo to afford the title compound. (M+H) found: 409.