HCID 178442423、化合物 → HCID 178442424、化合物

HRID 425410ノート

反応式

HRID 425410 の反応式
[CH3:1][C:2]([CH3:37])([CH2:35][CH3:36])[CH2:3][C:4]1[N:5]=[C:6]([C:9]2([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][N:29]=4)=[CH:24][CH:23]=3)[CH2:13][CH2:12][CH2:11][N:10]2C(OC(C)(C)C)=O)[NH:7][CH:8]=1>FC(F)(F)C(O)=O>[CH3:1][C:2]([CH3:37])([CH2:35][CH3:36])[CH2:3][C:4]1[N:5]=[C:6]([C:9]2([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][N:29]=4)=[CH:24][CH:23]=3)[CH2:13][CH2:12][CH2:11][NH:10]2)[NH:7][CH:8]=1

参加物

3

反応物 1

HCID 178442423HCID 178442423、化合物

生成物 1

HCID 178442424HCID 178442424、化合物

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

tert-Butyl 2-[4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]-2-[4-(5-fluoropyridin-2-yl)benzyl]pyrrolidine-1-carboxylate (45 mg, 0.089 mmol) was dissolved in trifluoroacetic acid (1 mL). After stirring at ambient temperature overnight, the reaction mixture was concentrated in vacuo to afford the title compound. 1H NMR (500 MHz, CD3OD) δ 8.48 (d, J=2.5 Hz, 1 H), 8.28 (br s, 1 H), 7.83 (dd, J=8.7, 4.2 Hz, 1 H), 7.79 (d, J=8.0 Hz, 2 H), 7.64 (td, J=8.5, 3.0 Hz, 1 H), 6.97 (d, J=8.0 Hz, 2 H), 6.86 (s, 1 H), 3.45-3.39 (m, 3 H), 3.24-3.17 (m, 1 H), 2.52-2.41 (m, 1 H), 2.45 (s, 2 H), 2.33-2.25 (m, 1 H), 2.22-2.13 (m, 1 H), 1.91-1.82 (m, 1 H), 1.22 (q, J=15.0, 7.5 Hz, 2 H), 0.84 (t, J=7.5 Hz, 3 H), 0.81 (s, 6 H); (M+H) found: 407.

後処理

  1. concentrationthe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-5974cc8e10d746728d12ff4bcde01033
出典データセット
uspto-grants-2012_01
特許番号
US08106070B2

反応ノート

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